Welcome to The Pearl Log — where post-shift wisdom surfaces, one shiny clinical take at a time. Some pearls are fresh, some are rough, all are found under pressure.
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Apixaban or Rivaroxaban for VTE?
Apixaban and rivaroxaban both block factor Xa, but real-world data give apixaban the edge. Across AFib and VTE cohorts, apixaban consistently shows lower rates of major and GI bleeding with similar efficacy. Rivaroxaban’s once-daily dosing helps adherence, but that convenience trades off a bit of safety margin. Until head-to-head RCTs land, patients will probably fare better on apixaban.
Leukocytoclastic Vasculitis and Bactrim.
Bactrim (TMP-SMX) is a go-to for UTIs and MRSA skin infections, but it can bite back. Beyond GI upset, it carries risks like SJS, cytopenias, and rare leukocytoclastic vasculitis.